A randomized trial of short-course ciprofloxacin, ofloxacin, or trimethoprim/sulfamethoxazole for the treatment of acute urinary tract infection in women

摘要: Abstract PURPOSE: Bladder infections are very common in otherwise healthy women, and short-course antimicrobial treatment appears effective for many episodes of cystitis. This study reports the results ciprofloxacin, ofloxacin, trimethoprim/sulfamethoxazole therapy. PATIENTS AND METHODS: We performed a randomized, double-blind efficacy safety 3-day course oral ciprofloxacin 100 mg twice daily, ofloxacin 200 or 160/800 daily women with acute, uncomplicated, symptomatic lower urinary tract infection. RESULTS: A total 866 patients were enrolled, whom 688 (79%) evaluated (229 treated 228 trimethoprim/sulfamethoxazole, 231 ofloxacin). The most frequent reason exclusion was failure to identify pretreatment pathogen. commonly isolated pathogen Escherichia coli (81%). Eradication at end therapy occurred 94% 93% 97% ofloxacin-treated patients. At follow-up evaluation 4 6 weeks, recurrence rates (relapse reinfection) 11% 16% 13% group. Clinical success 95% 96% groups. frequency all adverse events 31% 41% 39% ( P = 0.03). Premature discontinuation drug due an event more trimethoprim/sulfamethoxazole-treated (n 9) compared those given 2) 1; 0.02). CONCLUSION: Ciprofloxacin, had similar when 3 days treat symptomatic, uncomplicated infection women.