Red cell transfusions as an independent risk for mortality in critically ill children

摘要: Severity of illness is an important consideration in making the decision to transfuse as it sicker patient that often needs a red cell transfusion. Red blood (RBC) transfusions could potentially have direct effects and interact with presenting by contributing pathologies such multi-organ dysfunction acute lung injury thus exerting considerable impact on overall morbidity mortality. In this study, we examine if transfusion independent predictor mortality, or outcomes are merely result initial severity predicted Pediatric Risk Mortality (PRISM) III, Index (PIM2), day 1 Logistic Organ Dysfunction (PELOD) scores. A single center retrospective study was conducted using data from prospectively maintained database center-specific at our pediatric ICU between January 2009 December 2012. Multivariate regression used control for clinical findings, therapy, scores, mortality dependent variable. Likelihood ratios area under curve were test fidelity scores comparing transfused vs. non-transfused patients. There 4975 admissions met entry criteria. multivariate analysis, PRISM III serum hemoglobin significant predictors (p < 0.05). Transfused subjects distinctly disparate, so differences. age, volume transfused, vasoactive agents significantly associated whereas not. substantial number (45 %) occurred first 24 h, patients later (24–48 h) more likely die compared earlier time point. ratio testing revealed statistically differences scoring systems predict This suggests RBC risk factor severity. The timing related strongest remained outside purview scoring, these happened beyond collection most systems.