Effect of acyclic polyisoprenoids on the biosynthesis of mannose-labeled glycolipids in rat liver microsomes
作者： Manabu Murakami , Yasutoshi Muto , Hisataka Moriwaki , Toshiharu Ohgo
DOI: 10.1016/0006-291X(81)90507-6
关键词: Endogeny 、 In vitro 、 Glycolipid 、 Phosphorylation 、 Biosynthesis 、 Acceptor 、 Chemistry 、 Mannosyltransferase activity 、 Mannose 、 Stereochemistry 、 Biochemistry
摘要: Abstract The effect of the acyclic polyisoprenoid (C20); geranylgeranyl-acetone (GGA) and its derivatives on mannolipid formation from GDP-mannose in rat liver microsomes was studied. Remarkable increases biosynthesis (Rf 0.24 and/or Rf 0.50) were observed by vitro additions GGA, hydroxylated compound (GGA-OH) phosphorylated material (GGA-OP). These results strongly suggest that GGA-OP is involved 0.24) as an acceptor, analogy to retinylphosphate. On other hand, mechanism for increased endogenous GGA GGA-OH attributable enhancement mannosyltransferase activity.
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