Mutation of the Multiple Endocrine Neoplasia type 1 gene in nonfamilial malignant tumors of the endocrine pancreas
作者： Ola Hessman , Tobias Carling , Göran Åkerström , Per Hellman , Britt Skogseid
DOI:
关键词: Pancreas 、 Gene mutation 、 Multiple endocrine neoplasia 、 Cancer research 、 MEN1 、 Endocrine system 、 Carcinogenesis 、 Loss of heterozygosity 、 Biology 、 Pancreatic disease
摘要: Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations the MEN1 gene, located at 11q13, have been demonstrated in kindreds, and loss heterozygosity (LOH) on 11q13 together with somatic detected 20% nonfamilial parathyroid tumors. Here, we examine 11 non-MEN1 malignant pancreas, 9 nonfunctioning tumors, 2 glucagonomas. LOH least one informative locus was found 70% Three displayed gene whereas corresponding germ-line DNA normal. These findings support hypothesis contribute to tumorigenesis nonfamilial,
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