Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.
作者： John K. Cowell , Farlyn Z. Hudson , Mingqiang Ren , Jeffrey R. Lee , Qi-kui Chen
DOI: 10.1186/S12885-016-2105-8
关键词: Surgical oncology 、 Biology 、 Cell culture 、 Regulation of gene expression 、 Biomarker (medicine) 、 Colorectal cancer 、 Cancer 、 In vivo 、 Internal medicine 、 Oncology 、 Motility
摘要: Transgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin cancer controversial, a number studies have shown elevated levels correlate with aggressive tumor behavior, advanced stage, and poor prognosis. Here we sought to determine more directly by determining whether experimental manipulation colorectal (CRC) cells led changes metastatic potential vivo.
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