Influence of Polymorphic Transformations on Gelation of Tripalmitin Solid Lipid Nanoparticle Suspensions

摘要: Solid lipid nanoparticle (SLN) suspensions, which consist of submicron-sized crystalline particles dispersed within an aqueous medium, can be used to encapsulate, protect and deliver lipophilic functional components. Nevertheless, SLN suspensions are susceptible particle aggregation gelation during their preparation storage, potentially limits industrial utilization. In this study, we examined the behavior composed 10 wt% tripalmitin (r < 150 nm) stabilized by 1.5% Tween 20. The surfactant solution were homogenized above melting temperature cooled under controlled conditions initiate formation. storage was then shear rheometry, differential scanning calorimetry (DSC), light scattering microscopy. Rheology measurements indicated that times decreased with increasing temperature, e.g., samples formed weak gels after 62, 23, min at 1, 5, °C, respectively. DSC revealed increasingly rapid α- β-polymorphic transformations in dispersions stored We propose observed associated a change shape nanoparticles from spherical (α-form) non-spherical (β-form) when they undergo polymorphic transition. When there is no longer sufficient present completely cover phase, promotes through hydrophobic attraction. Our results have important implications for design fabrication stable suspensions.