Allelic Loss on Chromosome 17 in Ductal Carcinoma in Situ of the Breast
作者： Helen R. Donis-Keller , Alastair M. Thompson , Keri Fair , Samuel A. Wells , Matthew Holt
DOI:
关键词: Chromosome 17 (human) 、 Breast cancer 、 Carcinoma 、 Microdissection 、 Pathology 、 Carcinoma in situ 、 Biology 、 Carcinogenesis 、 Cancer research 、 Ductal carcinoma 、 Loss of heterozygosity
摘要: Multiple tumor suppressor genes are implicated in the oncogenesis and progression of invasive carcinoma breast. To investigate chronology genetic changes we studied loss heterozygosity on chromosome 17 ductal situ, a preinvasive breast cancer. A microdissection technique was used to separate from normal stromal cells prior DNA extraction assayed mainly using simple sequence repeat polymorphism markers polymerase chain reaction. Loss 17p observed 8 28 tumors (29%) when compared with control DNA, whereas no seen 17q, suggesting that at least one locus is involved early development
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