The Use of Mouse Models to Study Leukemia/Lymphoma and Assess Therapeutic Approaches
作者： William Siders
DOI: 10.1007/978-1-60761-968-0_14
关键词: Lymphoma 、 Cancer 、 Ofatumumab 、 Genetically modified mouse 、 Leukemia 、 Cancer research 、 Epratuzumab 、 Stromal cell 、 Genetically Engineered Mouse 、 Medicine
摘要: The fields of leukemia and lymphoma research have significantly advanced over the recent years as a result establishment cell lines that reflect several aspects human disease. These been employed in all phases preclinical from immunization mice to generate new therapeutic antibodies proof concept target validation experiments. In addition, transgenic mouse or genetically engineered models developed recapitulate many both lymphoma. are particularly well suited exploration interactions between tumor stromal cells progression cancer it relates its microenvironment. Therapeutic including ofatumumab epratuzumab currently undergoing clinical trial evaluation based on their activity such these. Xenograft especially instrumental studies addressing mechanism action evaluating combination therapies. This chapter will primarily explore use xenograft systems for approaches.
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