Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery.
作者： Veronique A. J. Smits , Ignacio Alonso-de Vega , Daniël O. Warmerdam
DOI: 10.1080/15384101.2020.1796037
关键词: Cohesin complex 、 Chromatin remodeling 、 Cell biology 、 Histone 、 Biology 、 G2-M DNA damage checkpoint 、 Chromatin 、 Establishment of sister chromatid cohesion 、 DNA damage 、 DNA repair
摘要: Chromatin plays a pivotal role in regulating the DNA damage response and during double-strand break repair. Upon generation of breaks, chromatin structure is altered by post-translational modifications histones remodeling. How structure, epigenetic information that it carries, reestablished after completion repair remains unclear though. Also, how these processes influence recovery cell cycle poorly understood. We recently performed reverse genetic screen for novel regulators control checkpoint damage. Here we discuss implications PHD finger protein 6 (PHF6) additional candidates from NuA4 ATPase-dependent chromatin-remodeling complex Cohesin complex, required sister chromatid cohesion, more detail. In addition, potential this function PHF6 cancer development treatment reviewed.
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