Tracer kinetic modeling: Basics and concepts

作者: Kjell Erlandsson

DOI: 10.1007/978-3-540-85962-8_16

关键词: Statistical physicsEngineering physicsInput functionTracer kineticArterial input functionTime pointComputer science

摘要: In nuclear medicine all studies are dynamic. This may seem like a controversial statement as most performed in departments consist of single static scan. However, even this case, the temporal dimension plays an important role terms time point for scan after administration tracer well its length.

参考文章(52)
R. Kawai, R. E. Carson, B. Dunn, A. H. Newman, K. C. Rice, R. G. Blasberg, Regional brain measurement of Bmax and KD with the opiate antagonist cyclofoxy: equilibrium studies in the conscious rat. Journal of Cerebral Blood Flow and Metabolism. ,vol. 11, pp. 529- 544 ,(1991) , 10.1038/JCBFM.1991.102
James E. Holden, Salma Jivan, Thomas J. Ruth, Doris J. Doudet, In vivo receptor assay with multiple ligand concentrations: an equilibrium approach. Journal of Cerebral Blood Flow and Metabolism. ,vol. 22, pp. 1132- 1141 ,(2002) , 10.1097/00004647-200209000-00011
George Scatchard, The Attractions of Proteins for Small Molecules and Ions Annals of the New York Academy of Sciences. ,vol. 51, pp. 660- 672 ,(1949) , 10.1111/J.1749-6632.1949.TB27297.X
Heok K. Cheow, Demetrius D. Voutnis, John W. Evans, Katy R. Szczepura, E. Anna Swift, Nicholas J. Bird, Prina Ruparelia, Chandra K. Solanki, James R. Ballinger, Edwin R. Chilvers, Stephen J. Middleton, A. Michael Peters, Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 32, pp. 329- 337 ,(2005) , 10.1007/S00259-004-1617-7
Richard E Carson, PET physiological measurements using constant infusion. Nuclear Medicine and Biology. ,vol. 27, pp. 657- 660 ,(2000) , 10.1016/S0969-8051(00)00138-4
R Todd Ogden, Ashish Ojha, Kjell Erlandsson, Maria A Oquendo, J John Mann, Ramin V Parsey, In vivo quantification of serotonin transporters using [11C]DASB and positron emission tomography in humans : modeling considerations Journal of Cerebral Blood Flow and Metabolism. ,vol. 27, pp. 205- 217 ,(2007) , 10.1038/SJ.JCBFM.9600329
Robert W. Kerwin, Lyn S. Pilowsky, Traditional receptor theory and its application to neuroreceptor measurements in functional imaging. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 22, pp. 699- 710 ,(1995) , 10.1007/BF01254574
R. A. Koeppe, V. A. Holthoff, K. A. Frey, M. R. Kilbourn, D. E. Kuhl, Compartmental Analysis of [11C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography Journal of Cerebral Blood Flow and Metabolism. ,vol. 11, pp. 735- 744 ,(1991) , 10.1038/JCBFM.1991.130
Marc Laruelle, The role of model-based methods in the development of single scan techniques Nuclear Medicine and Biology. ,vol. 27, pp. 637- 642 ,(2000) , 10.1016/S0969-8051(00)00142-6
Roger N. Gunn, Steve R. Gunn, Federico E. Turkheimer, John A. D. Aston, Vincent J. Cunningham, Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling Journal of Cerebral Blood Flow & Metabolism. ,vol. 22, pp. 1425- 1439 ,(2002) , 10.1097/01.WCB.0000045042.03034.42