Topiramate in the long-term treatment of binge-eating disorder associated with obesity.

摘要: Background: This study assessed the long-term effectiveness and tolerability of topiramate in binge-eating disorder (BED) with obesity. Method: Sixty-one patients BED (DSM-IV-TR criteria) obesity enrolled a 14-week, single-center, randomized, double-blind, placebo-controlled study. Completers (N = 35) were offered participation 42-week, open-label extension trial topiramate. Fifteen who received 16 placebo double-blind entered trial. Topiramate was titrated from 25 mg/day to maximum 600 mg/day. The primary endpoint change baseline final visit weekly binge frequency using last observation carried forward for all Baseline receiving beginning controlled study; placebo, Open-label data gathered December 1998 November 2000. Results: Forty-four (31 plus 13 only) at least 1 dose topiramate; 43 provided outcome measures median 250 Mean declined significantly (-3.2; p <.001), 15 during studies (-4.0; only (-2.5; =.044). Patients also exhibited statistically significant reduction body weight. most common reasons discontinuation protocol nonadherence 17) adverse events 14). Conclusion: treatment associated enduring improvement some but high rate.