Pharmaceutical compositions of microbially produced interleukin-2

作者: Terrance A. Taforo , Pete M. Fernandes

DOI:

关键词: Interleukin 2Recombinant DNASodium dodecyl sulfateMannitolSolubilityChromatographyChemistryWater solubleAqueous solution

摘要: A sterile, stable lyophilized formulation of selectively oxidized microbially produced recombinant IL-2 in which the is admixed with a water soluble carrier such as mannitol that provides bulk, and sufficient amount sodium dodecyl sulfate to ensure solubility water. The suitable for reconstitution aqueous injections parenteral administration it well tolerated human patients. FIG. 1 illustrates preferred method purifying use preparing formulations present invention.

参考文章(7)
Sidney Norman Richmond California Us Wolfe, Ze'ev Berkeley California Us Shaked, Controlled oxidation of microbially produced cysteine-containing proteins ,(1985)
Haruo Onda, Kyozo Tsukamoto, Shuji Hinuma, Messenger RNA, production and use thereof ,(1982)
Alvin S. Stern, Homogeneous human interleukin 2 ,(1982)
Leo S. Lin, David F. Mark, Shi-da Y. Lu, Human recombinant interleukin-2 muteins ,(1983)