作者: Terrance A. Taforo , Pete M. Fernandes
DOI:
关键词: Interleukin 2 、 Recombinant DNA 、 Sodium dodecyl sulfate 、 Mannitol 、 Solubility 、 Chromatography 、 Chemistry 、 Water soluble 、 Aqueous solution
摘要: A sterile, stable lyophilized formulation of selectively oxidized microbially produced recombinant IL-2 in which the is admixed with a water soluble carrier such as mannitol that provides bulk, and sufficient amount sodium dodecyl sulfate to ensure solubility water. The suitable for reconstitution aqueous injections parenteral administration it well tolerated human patients. FIG. 1 illustrates preferred method purifying use preparing formulations present invention.