The mortality and hospitalization rates associated with the long interdialytic gap in thrice-weekly hemodialysis patients

作者: James Fotheringham , Damian G. Fogarty , Meguid El Nahas , Michael J. Campbell , Ken Farrington

DOI: 10.1038/KI.2015.141

关键词: Cause of deathIncidence (epidemiology)Survival analysisCohortSudden deathMedicineRate ratioHemodialysisDialysisPediatricsEmergency medicine

摘要: Excess mortality and hospitalization have been identified after the 2-day gap in thrice-weekly hemodialysis patients compared with 1-day intervals, although findings vary internationally. Here we aimed to identify factors associated events England using an incident cohort of 5864 from years 2002 2006 inclusive UK Renal Registry linked data. Higher admission rates were seen irrespective whether dialysis sequence commenced on a Monday or Tuesday (2.4 per year vs. 1.4 for rest week, rate ratio 1.7). The greatest differences admitted fluid overload conditions high risk overload. Increased following was similarly independent session pattern (20.5 16.7 100 patient years, 1.22), these increases being driven by out-of-hospital death (rate 1.59 1.06 in-hospital death). Non-white had overall survival advantage, increased found only whites. Thus, may increase hospital that relate higher incidence sudden death. Future work should focus exploring interventions subgroups.

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