Regulatory dendritic cells for human organ transplantation.

摘要: Abstract Current immunosuppressive (IS) regimens used to prevent organ allograft rejection have well-recognized side effects, that include enhanced risk of infection and certain types cancer, metabolic disorders, cardiovascular disease, renal complications failure control chronic rejection. The life-long dependency patients on these IS agents reflects their inability induce donor-specific tolerance. Extensive studies in rodent non-human primate models demonstrated the ability adoptively-transferred regulatory immune cells (either myeloid or T cells) promote transplant Consequently, there is considerable interest potential cell therapy allow safe minimization/complete withdrawal immunosuppression promotion tolerance clinic. Here, we review properties dendritic (DCreg) with a focus approaches being taken generate human DCreg for clinical testing. We also document early phase trials are underway assess transplantation as well autoimmune disorders.