Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis
作者： Thomas Ryckmans , Martin P. Edwards , Val A. Horne , Ana Monica Correia , Dafydd R. Owen
DOI: 10.1016/J.BMCL.2009.05.062
关键词: Metabolic stability 、 Bicyclic molecule 、 Lipophilic efficiency 、 Lipophilicity 、 Stereochemistry 、 Sulfonamide 、 Chemical synthesis 、 Chemistry 、 Rapid assessment 、 Agonist
摘要: A series of libraries were designed using the 1-(cyclopropylmethyl)-2-alkyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-5-ium templates 2a–b, and Sulfonamide derivatives 11a–n …
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