Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis
作者： C. Verpelli , G. Piccoli , C. Zibetti , A. Zanchi , F. Gardoni
DOI: 10.1523/JNEUROSCI.0119-10.2010
关键词: Chemistry 、 Cell biology 、 Neuroscience 、 Gene knockdown 、 Translation (biology) 、 Phosphorylation 、 Signal transduction 、 RNA interference 、 Metabotropic glutamate receptor 、 EEF2 、 Dendritic spine
摘要: Activity-dependent changes in synaptic structure and spine morphology are required for learning memory, depend on protein translation. We show that the kinase eukaryotic elongation factor 2 (eEF2K) regulates dendritic stability by modulating activity-dependent BDNF synthesis. Specifically RNAi knockdown of eEF2K reduces inhibits expression; whereas overexpression a constitutively activated induces maturation increases expression BDNF. Furthermore, rescues reduced eEF2K. also mGluR/EF2K-induced eEF2 phosphorylation. propose eEF2K/eEF2 pathway is key biochemical sensor couple neuronal activity to plasticity, controlling translation
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