Risk Factors for Declining Ankle-Brachial Index in Men and Women 65 Years or Older

摘要: Background An ankle-brachial index (ABI) of less than 0.9 is a noninvasive measure lower extremity arterial disease and predictor cardiovascular events. Little information available on longitudinal change in ABI or risk factors for declining community-based population. Methods To assess decline, we studied 5888 participants the Cardiovascular Health Study cohort (men women 65 years older). We measured 1992-1993 again 1998-1999. At baseline, excluded individuals with an 0.9, greater 1.4, confirmed symptomatic (n = 823). The group decline included 218 0.15 to less. comparison comprised remaining 2071 follow-up ABI. Results percentage was 9.5% over 6 follow-up. mean ± SD 0.33 ± 0.12 cases 0.02 ± 0.13 noncases. Independent predictors reported as odds ratios, were age, 1.96 (95% confidence interval [CI], 1.42-2.71) 75 84 3.79 CI, 1.36-10.5) those older 85 compared younger years; current cigarette use, 1.74 1.02-2.96); hypertension, 1.64 1.18-2.28); diabetes, 1.77 1.14-2.76); higher low-density lipoprotein cholesterol level, 1.60 1.03-2.51), lipid-lowering drug use 1.05-2.89). Conclusion Worsening disease, assessed occurred this elderly associated modifiable vascular factors.