[Serum thiopental values, spontaneous frontal muscle electromyography activity and compressed EEG amplitudes and frequency values in thiopental infusion anesthesia].

摘要: Serum thiopentone (S-Thiop) was estimated every 10 minutes using a new high performance liquid chromatographic method during fentanyl-bolus-complemented (0.01 mg) infusion anaesthesia (bolus of 5 mg/kg, dosis 23.7 mg/min) for laryngo-microscopic procedures. Before stopping the after 18/17 min (SD 8/5) (male/female) S-Thiop (mean (SD) range) 16.0/12.4 (4.6/5.7) 5.9-26.8/5.1-26.6 mg/l; stop 12.8/10.5 (4.5/5.3) 7.6-25.5/4.5-23.4 mg/l. Patients reacted to verbal command 11.5 (10.3) 11-81 min. There were no clinically relevant correlations between and frontal EMG compressed 1-channel-EEG (ABM, Datex, Helsinki), nor with data recorded recovery. Reasons may be: total depolarisation block caused by succinylcholine; compressing EEG; subjective influences on recording recovery data; sampling in intervals instead at certain points course. We still recommend this i.v.-anaesthesia short time endolaryngeal procedures need; before longer periods additional pharmacokinetic studies should be performed.