Bone Material Strength as Measured by Microindentation In Vivo Is Decreased in Patients With Fragility Fractures Independently of Bone Mineral Density
作者： Frank Malgo , Neveen A. T. Hamdy , Socrates E. Papapoulos , Natasha M. Appelman-Dijkstra
DOI: 10.1210/JC.2014-4346
关键词: Fragility 、 Bone mineral 、 Osteoporosis 、 Surgery 、 Medicine 、 Context (language use) 、 Fracture (geology) 、 Endocrinology 、 FRAX 、 Internal medicine 、 Urology 、 Femoral neck 、 Osteopenia
摘要: Context: Bone mineral density (BMD) does not fully capture fracture risk as the majority of fractures occur in patients with osteopenia, suggesting that altered bone material properties and changes microarchitecture may contribute to risk. Objective: This study aimed evaluate relationship between strength (BMS), measured by microindentation vivo, low mass. Methods: BMS was 90 (mean age, 61.0 y; range, 40.4–85.5 y) mass or without a fragility fracture. Sixty-three had sustained one more fractures. Results: There significant negative correlation age (r = −0.539; P < .001) 10-year probability inclusion femoral neck BMD calculated FRAX −0.383; .001 r −0.426; .001, respectively). values were lower compared nonfracture (79.9 ± 0.6 vs 82.4...
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