Regulatory crosstalk and interference between the PCB 126 stimulated AHR and hypoxia stimulated HIF-1α signaling pathways
作者： Sabine Ulrike Vorrink
关键词: Internal medicine 、 Trichostatin A 、 Cell biology 、 Chemistry 、 Crosstalk (biology) 、 Signal transduction 、 Hypoxia-inducible factors 、 Endocrinology 、 Cell culture 、 Epigenetics 、 Bisulfite sequencing 、 Chromatin
摘要: 76 Introduction 77 Methodological approaches to query epigenetic regulation 79 Chromatin accessibility Bisulfite sequencing 80 Trichostatin A and 5-Aza-2'-deoxycytidine treatment 81 Other methods assess 82 Materials Methods 83 Chemicals PCB Cell lines cell culture conditions Quantitative real-time RT-PCR 84 Isolation of nuclear extracts chromatin 85 5-Aza-dC TSA 86 Statistical analysis 87 Results 88 Differential expression CYP1A1 mRNA in HepG2 WRL68 cells show regions open closed along the promoter increases 89
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