Action spectrum of photoactivated phthalocyanine AIS2Pc in tumor bearing mice.

摘要: The action spectrum of disulfonated aluminum phthalocyanine (AIS2-Pc) as a photosensitizer for photodynamic therapy (PDT) was evaluated in vivo from 640 to 710 nm on two murine tumors with different biological properties. Mice bearing MS-2 fibrosarcoma and mice the pigmented tumor B16 melanoma were injected 5 mg/kg AIS2Pc irradiated light dose 50 mW 10 min 100 melanoma. both presents red shift respect absorption saline. effectiveness is limited short wavelengths (less than or equal 655 less 660 B16), whereas it increases at longer reaches its maximum peak (672 nm). For beyond 672 activity remains up despite significant decrease absorption. results obtained seem therefore indicate that an appreciable modification takes place when incorporated into tissues following systematic administration.