Structure-based design of novel potent nonpeptide thrombin inhibitors.
作者： Norbert H. Hauel , Herbert Nar , Henning Priepke , Uwe Ries , Jean-Marie Stassen
DOI: 10.1021/JM0109513
关键词: Context (language use) 、 Hydrophobic effect 、 Thrombin 、 Enzyme inhibitor 、 Chemistry 、 Prodrug 、 In vivo 、 Stereochemistry 、 Discovery and development of direct thrombin inhibitors 、 Serine protease
摘要: … with bovine thrombin, we have designed a new structural class of … our hypothesis at this point was that the diatomic linker facilitates a better positioning of the benzamidine group …
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