Nalmefene: blockade of intravenous morphine challenge effects in opioid abusing humans
作者： Hendrée E. Jones , Rolley E. Johnson , Paul J. Fudala , Jack E. Henningfield , Stephen J. Heishman
DOI: 10.1016/S0376-8716(00)80005-8
关键词: Randomized controlled trial 、 Crossover study 、 Nalmefene 、 Medicine 、 Antagonist 、 Narcotic antagonist 、 Anesthesia 、 Blockade 、 Morphine 、 Opioid
摘要: No studies have assessed the dose-effect or duration of opioid blockade in abusers produced by oral nalmefene, a micro-opioid antagonist. The present study examined profile and time course nalmefene subjective physiological effects intravenous morphine. To assess these effects, seven received (0, 50 100 mg) followed morphine 10 20 challenges every 24 h for 96 using Latin square randomized cross-over design. varied measure dose. Both mg blocked morphine's up to 48 h.
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