Oligodeoxynucleotides Without CpG Motifs Work as Adjuvant for the Induction of Th2 Differentiation in a Sequence-Independent Manner
作者： Kunio Sano , Hidekazu Shirota , Tadashi Terui , Toshio Hattori , Gen Tamura
DOI: 10.4049/JIMMUNOL.170.5.2367
关键词: Cytokine 、 Immune system 、 Transgene 、 Receptor 、 Immunology 、 Cell biology 、 CpG site 、 Effector 、 Biology 、 Toll-Like Receptor 9 、 Cell
摘要: The outcomes of immune responses are regulated by various parameters including how Ags handled APCs. In this study, we describe the intrinsic immunomodulatory characteristics oligodeoxynucleotides (ODNs) that improve Ag presentation ODNs (20-mer) containing CpG motifs induced strong Th1-skewed responses. contrast, those without enhanced cytokine production effector Th cells particular skewing toward Th1 or differentiation unprimed CD4 + T Th2 cells. These functional features were prominently envisaged when conjugated to Ag, and underlain facilitated binding ODN-conjugated Ia Despite differences between with motifs, both bound similar affinity kinetics. Immunoenhancing activities not sequence-dependent; characteristics, facilitation capture, enhancement cell responses, induction cells, shared randomly synthesized Ag. This is first study suggesting ODNs, independent sequences, enhance through promoted capture
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