Anti-HSV-1 activity of Euclea natalensis
作者： N. Lall , J.J.M. Meyer , M.B. Taylor , J. van Staden
DOI: 10.1016/S0254-6299(15)30118-6
关键词: Virus 、 Biology 、 Biochemistry 、 Vervet monkey 、 Naphthoquinone 、 Cell culture 、 Herpes simplex virus 、 Euclea natalensis 、 Viability assay 、 Cell growth 、 Molecular biology
摘要: The inhibitory effect of crude extracts Euclea natalensis A. DC. and a naphthoquinone, diospyrin, isolated from this species, was investigated against herpes simplex virus Type 1 (HSV-1) for activity by in vitro studies on primary vervet monkey kidney (VK) cells. Cell toxicity monitored determining the diospyrin monolayers VK dose plant samples that inhibited 50% cell growth (ID 50 ) after incubation period 0.1 mg ml -1 0.2 mg ml acetone water extracts, respectively. Diospyrin exhibited an ID 0.02 mg ml extract roots least toxic to cultures replication HSV-1 moderately at concentration –1 . had no virus. However, concentrations ranging , as shown reduction virus- induced cytopathogenic effects protection cells viability assay
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