Thrombolysis for central venous occlusion causing bilateral chylothorax in a patient with down syndrome.

作者: Nathan Manghat , John Hancock , Mark Walsh , Mark Puckett , Richard Noble

DOI: 10.1097/01.RVI.0000126808.82358.6D

关键词: Subclavian veinAxillary veinChylothoraxAngioplastyThrombolysisSurgeryDown syndromeVenous thrombosisMedicineFibrinolytic agent

摘要: A 20-year-old woman with Down syndrome (trisomy 21) and acute lymphoblastic leukemia presented severe respiratory compromise secondary to bilateral chylothorax as a result of central venous thrombosis extensive upper-limb deep thrombosis. The was successfully managed by catheter-directed thrombolysis angioplasty the occlusions. development likely have been multifactorial. It is recognized that there an increased incidence congenital lymphatic anomalies in syndrome, which may contributing factor this patient. This report illustrates angiographic findings, demonstrates successful vascular recanalization, discusses etiology management chylothorax. case also contribute expanding evidence support selected clinical circumstances.

参考文章(23)
Roland Berger, Acute lymphoblastic leukemia and chromosome 21 Cancer Genetics and Cytogenetics. ,vol. 94, pp. 8- 12 ,(1997) , 10.1016/S0165-4608(96)00351-2
K. Mathias, H. Jäger, J. Willaschek, B. Theophil, Interventionelle Radiologie bei zentralen venösen ObstruktionenDilatation – Stentimplantation – Thrombolyse Radiologe. ,vol. 38, pp. 606- 613 ,(1998) , 10.1007/S001170050399
CL Witte, MH Witte, P Crowe, R Greenlee, H Hoyme, Developmental disorders of the lymphatic system. Lymphology. ,vol. 26, pp. 156- 168 ,(1993)
Theophil B, Willaschek J, Jäger H, Mathias K, [Interventional radiology in central venous obstructions. Dilatation--stent implantation--thrombolysis]. Radiologe. ,vol. 38, pp. 606- ,(1998) , 10.1007/S001170050399
Patrick Haage, Timo Krings, Thomas Schmitz-Rode, Nontraumatic vascular emergencies: imaging and intervention in acute venous occlusion. European Radiology. ,vol. 12, pp. 2627- 2643 ,(2002) , 10.1007/S00330-002-1615-8
Selim M Arcasoy, Anil Vachani, Local and systemic thrombolytic therapy for acute venous thromboembolism. Clinics in Chest Medicine. ,vol. 24, pp. 73- 91 ,(2003) , 10.1016/S0272-5231(02)00051-5
James Hanna, Edward Truemper, Edward Burton, Superior vena cava thrombosis and chylothorax: relationship in pediatric nephrotic syndrome Pediatric Nephrology. ,vol. 11, pp. 20- 22 ,(1997) , 10.1007/S004670050225
A. Schulman, S. Fataar, R. Dalrymple, I. Tidbury, The lymphographic anatomy of chylothorax. British Journal of Radiology. ,vol. 51, pp. 420- 427 ,(1978) , 10.1259/0007-1285-51-606-420
Victor Marder, Thrombolytic Therapy: Current Status The New England Journal of Medicine. ,vol. 318, pp. 1585- 1595 ,(1988) , 10.1056/NEJM198806093182306