The role of the muscle metaboreflex in patients with chronic disease

摘要: Exercising muscle needs a constant supply of oxygen for the aerobic metabolism carbohydrate and fat, regulation blood to during exercise is therefore critical. Heart rate, stroke volume minute ventilation all increase exercise, sympathetic vasoconstriction diverts exercising muscle. It well recognised that receptors in skeletal play vital role flow, including sensitive products anaerobic such as lactate hydrogen ions: metaboreceptors. Activation metaboreflex signals need an leads cardiac output, non-essential organs. Exercise intolerance one most disabling symptoms patients with range cardiorespiratory diseases. Abnormalities favouring have been documented both chronic heart failure obstructive pulmonary disease (COPD), this thought be relevant limitation these Studies looking at demonstrated activity. abnormal generates greater quantities metabolites, leading increased metaboreceptor activation. This turn causes nervous system ventilatory response exercise. Patients COPD shown demonstrate similar abnormalities, so we hypothesised would also find activity group. It possible quantify by small group fatigue then isolating it from rest circulation sphygmomanometer cuff. traps metabolic prolonged stimulation can measured sustained pressure when compared control recovery without cuff inflation. The aims thesis were follows: (i) assess if determine whether more severe disease, (ii) supplementation oral creatine monohydrate alters activity, upper limb strength or endurance respiratory COPD, (iii) effects diabetic autonomic neuropathy on function, (iv) evaluate pulse transit time use measurement activity. In our first study, looked stable found rhythmic forearm followed post-exercise ischaemia led recovery. These findings are keeping previously published observations normal subjects failure. We there was no difference between groups moderate disease. We performed randomised, double-blind, placebo-controlled, crossover trial loading monohydrate. body weight peak inspiratory expiratory mouth pressures, but strength, recovery. A type I diabetes mellitus used study function. evidence neuropathy, suggesting afferent efferent limbs intact. Our final evaluated could Pulse defined taken wave travel two arterial sites, easily non-invasively measured. reflect tone. In healthy subjects, fell handgrip fall shows promise further studies required. comparing invasive measurements nerve particular interest.