Progressive Retinal Thinning in Sickle Cell Retinopathy.

摘要: Purpose To determine the rate of retinal thinning on spectral-domain (SD) OCT in patients with sickle cell compared controls. Design Retrospective, longitudinal study. Participants Patients and age-similar control SD-OCT macula volume scans at least 10 months apart were reviewed. Methods Automated segmentation was performed using Iowa Reference Algorithms to divide retina into 3 combined layers: superficial (retinal nerve fiber layer ganglion layer), middle (inner plexiform inner nuclear outer (outer pigment epithelium). The mean thickness each Early Treatment Diabetic Retinopathy Study (ETDRS) subfield recorded. change calculated a multilevel mixed-effects model. Main Outcome Measures superficial, middle, retina. Results Thirty-eight eyes 24 (age: 40 years, range 18–67 years; genotype: 12 hemoglobin SS, 11 SC, 1 not available) 30 followed average for 25.5 months. initial thinner group (superficial: 69.95 vs. 72.22 μm; middle: 65.24 71.22 outer: 171.37 175.55 μm). greater than (superficial: −0.89 vs. −0.41 μm/year; middle: −0.45 vs. +0.18 outer: −0.50 vs. −0.02 μm/year). statistically significant (P Conclusions exhibit progressive predominantly affecting that may represent chronic microvascular insult.