Neointimal Tissue Response at Sites of Coronary Stenting in Humans

摘要: Background—Experimental animal studies have shown that coronary stenting induces neointimal proliferation. However, the histopathological events after in humans not been studied systematically. Methods and Results—We investigated 11 stented arteries (9 Palmaz-Schatz stents, 1 Wiktor stent, ACS Multi-Link stent) obtained from patients who had died 2 days to 21 months stenting. We focused on gross, histological, immunohistochemical aspects of repair processes. Two developed symptoms restenosis. Serial sections were stained with antibodies against smooth muscle cells (SMCs), macrophages, endothelial cells. At 9 12 stenting, stent sites showed thrombus formation early neointima composed abundant macrophages α-actin–negative spindle From 64 on, all a distinct layer neointima, albeit varying degrees. In nonrestenotic lesions, thickening was ma...