When Worlds Collide-Mechanisms at the Interface between Phosphorylation and Ubiquitination.

摘要: Phosphorylation and ubiquitination are pervasive post-translational modifications that impact all processes inside eukaryotic cells. The role of each modification has been studied for decades, functional interplay between the two long demonstrated even more widely postulated. However, our understanding molecular features allow phosphorylation to control protein ubiquitin only recently begun build. Here, we review examples regulation phosphorylation, aiming describe mechanisms at level. In general, these illustrate as a versatile switch throughout pathways, primarily impacting kinase signalling in emphatic manner through scaffolding or degradation. Examples likely grow further advances biology, proteomics, computation system-level signalling. Many new cases could involve similar principles those described here, but extensive co-regulation systems leaves no doubt they still have many surprises store.