Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold.
作者： Michael S. Goligorsky
DOI: 10.1016/J.KRCP.2015.05.003
关键词: Mesenchymal phenotype 、 Premature senescence 、 Pathogenesis 、 Kidney disease 、 Cell 、 Medicine 、 Endothelial stem cell 、 Chronic Kidney Diseases 、 In patient 、 Bioinformatics
摘要: Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview ECD scans two decades studies performed my laboratory, from genetic analyses to proteomic metabolomics screens. I provide detailed description findings related premature senescence endothelial cells, transition mesenchymal phenotype, stages development ECD. Clinical utility some these illustrated data on laser-Doppler flowmetry imaging patients CKD. Some currently available emerging therapeutic options for management are briefly presented.
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Francesco Addabbo, Brian Ratliff, Hyeong-Cheon Park, Mei-Chuan Kuo, Zoltan Ungvari, Anna Ciszar, Boris Krasnikof, Komal Sodhi, Fung Zhang, Alberto Nasjletti, Michael S. Goligorsky, The Krebs Cycle and Mitochondrial Mass Are Early Victims of Endothelial Dysfunction The American Journal of Pathology. ,vol. 174, pp. 34- 43 ,(2009) , 10.2353/AJPATH.2009.080650
J D Catravas, L R Mills, K J Dobuler, C N Gillis, J S Lazo, Pulmonary endothelial dysfunction in the presence or absence of interstitial injury induced by intratracheally injected bleomycin in rabbits. The American review of respiratory disease. ,vol. 128, pp. 740- 746 ,(1983) , 10.1164/ARRD.1983.128.4.740
Hong Li, Michael S. Goligorsky, Endothelial gene responses to homocysteine: relation to atherosclerosis. Nephron Experimental Nephrology. ,vol. 10, pp. 164- 169 ,(2002) , 10.1159/000049911
F. Addabbo, Q. Chen, M.M. Rabadi, B.B. Ratliff, F. Zhang, A. Nasjletti, J.F. Jasmin, M. Lisanti, S.S. Gross, M. Goligorsky, PP004-SUN GLUTAMINE SUPPLEMENTATION ALLEVIATES VASCULOPATHY AND ALTERS PLASMA METABOLOME IN AN IN VIVO MODEL OF ENDOTHELIAL CELL DYSFUNCTION Clinical Nutrition Supplements. ,vol. 7, pp. 26- ,(2012) , 10.1016/S1744-1161(12)70056-X
Jeffrey M. Turner, Carolyn Bauer, Matthew K. Abramowitz, Michal L. Melamed, Thomas H. Hostetter, Treatment of chronic kidney disease Kidney International. ,vol. 81, pp. 351- 362 ,(2012) , 10.1038/KI.2011.380
Nicolas Pottier, Christelle Cauffiez, Michael Perrais, Pascal Barbry, Bernard Mari, FibromiRs: translating molecular discoveries into new anti-fibrotic drugs. Trends in Pharmacological Sciences. ,vol. 35, pp. 119- 126 ,(2014) , 10.1016/J.TIPS.2014.01.003
Toshio Miyata, Norio Suzuki, Charles van Ypersele de Strihou, Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology? Kidney International. ,vol. 84, pp. 693- 702 ,(2013) , 10.1038/KI.2013.74
A. Kruger, J. Stewart, R. Sahityani, E. O'Riordan, C. Thompson, S. Adler, R. Garrick, P. Vallance, M.S. Goligorsky, Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: Correlation with cardiovascular risk Kidney International. ,vol. 70, pp. 157- 164 ,(2006) , 10.1038/SJ.KI.5001511
Edmond O’Riordan, Natalia Mendelev, Susann Patschan, Daniel Patschan, Jonathan Eskander, Leona Cohen-Gould, Praveen Chander, Michael S. Goligorsky, Chronic NOS inhibition actuates endothelial-mesenchymal transformation. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 292, ,(2007) , 10.1152/AJPHEART.00560.2006
Eero Mervaala, Piet Finckenberg, Risto Lapatto, Dominik N. Müller, Joon-Keun Park, Ralf Dechend, Detlev Ganten, Heikki Vapaatalo, Friedrich C. Luft, Lipoic acid supplementation prevents angiotensin II–induced renal injury Kidney International. ,vol. 64, pp. 501- 508 ,(2003) , 10.1046/J.1523-1755.2003.00108.X