A perspective on the role of natriuretic peptides in amphibian osmoregulation.

摘要: The natriuretic peptide (NP) system is a complex family of peptides and receptors that primarily linked to the maintenance osmotic cardiovascular homeostasis. In amphibians, potential role(s) NPs complicated by range osmoregulatory strategies found in different tissues participate osmoregulation. Atrial NP, brain C-type NP have been isolated or cloned from number species, which has enabled physiological studies be performed with homologous peptides. addition, three types partially characterised. Natriuretic are always potent vasodilators amphibian blood vessels, ANP shown increase permeability microcirculation. perfused kidney, causes vasodilation, diuresis natriuresis caused an increased GFR rather than effects renal tubules. These data supported presence only on glomeruli vessels. bladder skin, function enigmatic because analysis skin yielded conflicting no clear role for being revealed. Overall, often direct effect, but some they inhibit AVT. there evidence can salt retention amphibians since it ability adrenocorticotrophic hormone angiotensin II stimulate corticosteroid secretion. It proposed important cardiac could control hypervolaemia during periods rapid rehydration, occurs terrestrial amphibians.