作者: Ralf G. Heine
DOI: 10.1159/000371700
关键词: Medicine 、 Pathology 、 Allergy 、 Enteropathy 、 Food allergy 、 Immunology 、 Elimination diet 、 Enterocolitis 、 Ingestion 、 Proctocolitis 、 Hypoallergenic
摘要: Gastrointestinal food allergies present during early childhood with a diverse range of symptoms. Cow's milk, soy and wheat are the three most common gastrointestinal allergens. Several clinical syndromes have been described, including protein-induced enteropathy, proctocolitis enterocolitis. In contrast immediate, IgE-mediated allergies, onset symptoms is delayed for at least 1-2 hours after ingestion in non-IgE-mediated allergic disorders. The pathophysiology these disorders poorly understood, useful vitro markers lacking. results skin prick test or measurement food-specific serum IgE level generally negative, although low-positive may occur. Diagnosis therefore relies on recognition particular phenotype as well demonstration clear improvement allergen elimination re-emergence upon challenge. There significant overlap between allergy several paediatric gastroenterological conditions, which lead to diagnostic confusion. treatment requires strict offending allergens until tolerance has developed. breast-fed infants, maternal diet often sufficient control formula-fed usually involves use an extensively hydrolysed amino acid-based formula. Apart from hypoallergenic formulae, solid diets children also need be kept free specific allergens, clinically indicated. nutritional progress infants young should carefully monitored, they undergo ongoing, regular protein reassessments by cautious challenges monitor possible development.