Immunity, emotions and stress with special reference to the mechanisms of stress effects on the immune system.

摘要: Evidence from a variety of sources supports the notion that stress and emotional distress may relate to dysfunction hypofunction immunologic system. We have experimental evidence some forms reduce primary secondary antibody response low dose antigen stimulation in rats adult responsivity be altered by early infantile experience. Mixed-sex group housing at high male-female ratios increases severity adjuvant-induced arthritis male rat. Graft-versus-host reactions are diminished food-limitation recipient animals. Sex segregated group-housed mice show larger murine virus-induced sarcomas when inoculated 6 9 months age than males housed individually with two or more females. Electric shock for 3 days prior inoculation virus reduces incidence size MSV tumors, while administered following tumor size. Female develop spontaneous fighting behavior significantly greater resistance tumors. Acutely ill schizophrenic patients relatively levels IgA IgG poorer short-term prognosis. Electrolytic lesions ventromedial posterior nuclei hypothalamus possibly also donor animals impair GVH reaction. Our findings suggest central nervous system affect thymus-derived lymphocytes (T-cells) play role cell-cell interaction release mediators reacting lymphocytes. Ultimately, we find affects macrophage, hormone-sensitive cell plays afferent, efferent limbs immune