Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review.
作者： J C Byrd , W J Edenfield , D J Shields , N A Dawson
DOI: 10.1200/JCO.1995.13.7.1800
关键词: Leukemia 、 Histopathology 、 Auer rod 、 Immunohistochemistry 、 Pathology 、 Myeloid 、 Myeloid sarcoma 、 Meningeal Leukemia 、 Leukemia cutis 、 Medicine
摘要: PURPOSETo discuss the predisposing risk factor for all forms of extramedullary leukemia (EML) and to review clinical features, prognostic significance, treatment strategies primary EML cutis (LC)/granulocytic sarcomas (GS) in setting acute nonlymphocytic (ANLL).METHODSA reports published since 1965 related (LC, GS, gingival hypertrophy, meningeal [ML]).RESULTSSeveral factors, including chromosomal abnormalities [t(8;21), inv(16)], cell-surface markers (CD56, CD2, CD4, CD7), French-American-British (FAB) subtype (M2, M4, M5), blast differentiation maturation, patient nutritional status, age, cellular immune dysfunction, high presenting leukocyte count, decreased Auer rods, have been associated with a higher incidence EML. Of 154 cases identified, 71 (46%) were initially misdiagnosed. The addition immunohistochemical stains can assist preventing such mis...
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