Genetic, antigenic and biological differences between strains of hepatitis A virus.

摘要: Abstract Recent studies have documented a considerable degree of genetic divergence among wild-type hepatitis A virus (HAV) strains recovered from different geographical locations. Human HAV can be grouped into four genotypes (I, II, III and VII) unique simian belong to three additional (IV, V VI). Between each these genotypes, the nucleotide sequence varies at 15–25% base positions in P1 region. Despite this, there is good evidence that most, if not all, human are closely related antigenically. In contrast, although Old World monkeys cross-reactive immunoassays employing polyclonal antibodies, significant antigenic differences strains. Nonetheless, because biological host range apparently preclude infection, this unlikely pose problem controlling infections with active immunization. Inactivated attenuated vaccines produced genotype I (HM175 or CR326) likely provide protection against all relevant