Promoter Polymorphisms in the Nitric Oxide Synthase 3 Gene Are Associated With Ischemic Stroke Susceptibility in Young Black Women
作者： Timothy D. Howard , Wayne H. Giles , Jianfeng Xu , Marcella A. Wozniak , Ann M. Malarcher
DOI: 10.1161/01.STR.0000177978.97428.53
关键词: Single-nucleotide polymorphism 、 Nitric oxide 、 Stroke 、 Candidate gene 、 Endocrinology 、 Haplotype 、 Pathology 、 Medicine 、 Population 、 Nitric Oxide Synthase Type III 、 Internal medicine 、 Allele
摘要: Background and Purpose— Endothelial nitric oxide exerts a variety of protective effects on endothelial cells blood vessels, therefore the synthase 3 gene (NOS3) is logical candidate for stroke susceptibility. Methods— We used population-based Stroke Prevention in Young Women case-control study to assess association five NOS3 polymorphisms 110 cases (46% black) with ischemic 206 controls (38% black), 15 44 years age. Polymorphisms included single nucleotide (SNPs) promoter region (−1468 T>A, −922 G>A, −786 T>C), 1 SNP exon 7 (G894T), insertion/deletion polymorphism within intron 4. Results— Significant associations both G>A T>C SNPs were observed black, but not white, population. This was attributable an increased prevalence A allele (OR=3.0, 95% CI=1.3 6.8; P=0.005) -786 T (OR=2.9, 6.4; cases...
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