MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture.
作者： Vincent H. Wu , Robert A. Smith , Sara Masoum , Dana N. Raugi , Selly Ba
DOI: 10.1128/AAC.00744-17
关键词: Virology 、 Biochemistry 、 Chemistry 、 4'-ethynyl-2-fluoro-2'-deoxyadenosine 、 Group A 、 EC50 、 Antiretroviral therapy 、 Drug resistance 、 Mutant 、 Human immunodeficiency virus (HIV)
摘要: … against HIV-2, we constructed a molecular model of HIV-2 RT with MK-8591-TP bound at the polymerase active site and compared the model to the published structure of the HIV-1 RT–…
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