Human 17β-Hydroxysteroid Dehydrogenase Type 5 is Inhibited by Dietary Flavonoids
作者： A. Krazeisen , R. Breitling , G. Möller , J. Adamski
DOI: 10.1007/978-1-4757-5235-9_14
关键词: Cofactor binding 、 Hydroxysteroid dehydrogenase 、 Coumestrol 、 Hydroxylation 、 Enzyme 、 Phytoestrogens 、 Flavones 、 Isoflavones 、 Chemistry 、 Biochemistry
摘要: Phytoestrogens contained in a vegetarian diet are supposed to have beneficial effects on the development and progression of variety endocrine-related cancers. We tested effect dietary phytoestrogens, especially flavonoids, activity human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD 5), key enzyme metabolism estrogens androgens. Our studies show that reductive oxidative inhibited by many compounds, zearalenone, coumestrol, quercetin biochanin A. Among flavones, inhibitor potency is enhanced with increased degree hydroxylation. The most effective inhibitors seem bind hydrophilic cofactor binding pocket enzyme.
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