Computational design of a pH-sensitive IgG binding protein

作者: E.-M. Strauch , S. J. Fleishman , D. Baker

DOI: 10.1073/PNAS.1313605111

关键词: IgG bindingProtein structureProtein ligandAffinity chromatographyBiologyProtein engineeringBinding proteinImmunoglobulin GPlasma protein bindingBiochemistry

摘要: Computational design provides the opportunity to program protein–protein interactions for desired applications. We used de novo protein interface design to generate a pH-dependent …

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