Photothermal cellular stimulation in functional bio-polymer interfaces
作者： Nicola Martino , Paul Feyen , Matteo Porro , Caterina Bossio , Elena Zucchetti
DOI: 10.1038/SREP08911
关键词: Nanotechnology 、 Thin film 、 Depolarization 、 Organic semiconductor 、 Membrane 、 Photothermal therapy 、 Polymer 、 Materials science 、 Membrane potential 、 Conjugated system
摘要: Hybrid interfaces between organic semiconductors and living tissues represent a new tool for in-vitro in-vivo applications, bearing huge potential, from basic researches to clinical applications. In particular, light sensitive conjugated polymers can be exploited as approach optical modulation of cellular activity. this work we focus on light-induced changes in the membrane potential Human Embryonic Kidney (HEK-293) cells grown top poly(3-hexylthiophene) (P3HT) thin film. On capacitive charging polymer interface, identify fully characterize two concomitant mechanisms, leading depolarization hyperpolarisation, both mediated by thermal effect. Our results usefully creation platform light-controlled cell manipulation, with possible applications neuroscience medicine.
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