The regulatory functions of proline and pyrroline-5-carboxylic acid.

摘要: Publisher Summary This chapter reviews the recent work on regulatory functions of proline and pyrroline-5-carboxylate presents a synthesis these within framework biologic regulation. As redox couple, provide mechanism for inter-compartmental intercellular transfer potential. The potential alters ratio NADP + /NADPH, thereby activating certain metabolic pathways. Although reduction is central in potential, interconversions proline, ornithine, glutamate with as obligate intermediate can also play role. end point this regulation formation purine ribonucleotides by both salvage de novo mechanisms. Proline are signals that be fine-tuned humoral factors to coordinate metabolism amino acids ribonucleotides. When from cell cell, function communicators.