Chapter 10 – Prions

作者: Dimitry Konstantinovich Lvov , Mikhail Yurievich Shchelkanov , Sergey Vladimirovich Alkhovsky , Petr Grigorievich Deryabin

DOI: 10.1016/B978-0-12-801742-5.00010-6

关键词: Prion proteinZoologyVirologyPRNPBiologyInterspecies transmissionTransmissible spongiform encephalopathyPopulationChronic wasting disease

摘要: Transmissible spongiform encephalopathy (TSE) is a unique group of zoonotic neurogenerative diseases, caused by prions and affecting animal humans. Prions define specific class infectious agents, all or nearly which are abnormal isoforms the host-encoded prion protein, PrP. Among TSEs chronic wasting disease (CWD) in cervids, has been demonstrated captive free-ranging mule deer, white-tailed elk, moose inlimited areas United States Canada. Estimating risk CWD emerging spreading Northern Eurasia much complicated great species diversity wild ungulates, populate an immense territory. But results genetic studies cervids have revealed that majority Russian moose’s, maral’s, population falls into high-risk for determined polymorphisms Prpn gene, encodes

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