High expression of cAMP responsive element binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer
作者： Ya-Wen Wang , Xu Chen , Ji-Wei Gao , Hui Zhang , Ran-Ran Ma
关键词: Oncology 、 CREB1 、 Cancer research 、 Biology 、 Western blot 、 Cancer 、 Lymph node 、 microRNA 、 Metastasis 、 Internal medicine 、 Immunohistochemistry 、 Biomarker (medicine)
摘要: cAMP responsive element binding protein 1 (CREB1) has been reported to be implicated in tumor development and progression of human cancers. However, the clinical significance regulatory mechanisms CREB1 expression gastric cancer remain largely unknown. In present study, immunohistochemistry was performed detect 185 primary tissues, 50 secondary lymph node metastatic foci nontumorous tissues. A prognostic model combining with TNM stage constructed by logistic regression analysis. Regulation miRNAs investigated luciferase reporter assay Western blot. It shown that highly expressed correlated metastasis, distant metastasis poor outcome cancer. The proven an independent prognosis predictor better than or alone. identified as a direct target miR-27b miR-200b, down-regulated miR-27b/miR-200b. We conclude is promising biomarker predict patient cancer, miR-27b/miR-200b-CREB1 pathway may serve potential molecular for treatment
impactjournals.com参考文章(37)
X. Tan, S. Wang, L. Zhu, C. Wu, B. Yin, J. Zhao, J. Yuan, B. Qiang, X. Peng, cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 15805- 15810 ,(2012) , 10.1073/PNAS.1207787109
J. D. Harrison, J. W. L. Fielding, Prognostic factors for gastric cancer influencing clinical practice. World Journal of Surgery. ,vol. 19, pp. 496- 500 ,(1995) , 10.1007/BF00294709
Ya-Wen Wang, Duan-Bo Shi, Ya-Min Liu, Yan-Lin Sun, Xu Chen, Shuai Xiang, Qiang Fu, Jun-Min Wei, Peng Gao, Aberrant expression of CD227 is correlated with tumor characteristics and invasiveness of breast carcinoma. Journal of Cancer Research and Clinical Oncology. ,vol. 140, pp. 1271- 1281 ,(2014) , 10.1007/S00432-014-1676-5
Bernhard Mayr, Marc Montminy, Transcriptional regulation by the phosphorylation-dependent factor CREB Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 599- 609 ,(2001) , 10.1038/35085068
Ya-Wen Wang, Duan-Bo Shi, Xu Chen, Chao Gao, Peng Gao, None, Clinicopathological Significance of MicroRNA-214 in Gastric Cancer and Its Effect on Cell Biological Behaviour PLoS ONE. ,vol. 9, pp. e91307- ,(2014) , 10.1371/JOURNAL.PONE.0091307
Ilka Oerlecke, Elke Bauer, Angela Dittmer, Benjamin Leyh, Jürgen Dittmer, Cyclic AMP enhances TGFβ responses of breast cancer cells by upregulating TGFβ receptor I expression. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0054261
Songjie Shen, Qiang Sun, Zhiyong Liang, Xiaojiang Cui, Xinyu Ren, Huan Chen, Xiao Zhang, Yidong Zhou, A Prognostic Model of Triple-Negative Breast Cancer Based on miR-27b-3p and Node Status PLoS ONE. ,vol. 9, pp. e100664- ,(2014) , 10.1371/JOURNAL.PONE.0100664
Gaorav P. Gupta, Joan Massagué, Cancer Metastasis: Building a Framework Cell. ,vol. 127, pp. 679- 695 ,(2006) , 10.1016/J.CELL.2006.11.001
Brock Humphries, Zhishan Wang, Aaron L. Oom, Theresa Fisher, Dongfeng Tan, Yuehua Cui, Yiguo Jiang, Chengfeng Yang, MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis. Carcinogenesis. ,vol. 35, pp. 2254- 2263 ,(2014) , 10.1093/CARCIN/BGU133
Harsh Dweep, Carsten Sticht, Priyanka Pandey, Norbert Gretz, miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes Journal of Biomedical Informatics. ,vol. 44, pp. 839- 847 ,(2011) , 10.1016/J.JBI.2011.05.002