Water and electrolyte content of cardiac and skeletal muscle in heart failure and myocardial infarction

摘要: Abstract The water and electrolyte content of cardiac skeletal muscle from patients dying congestive failure or recent myocardial infarction was compared with the composition specimens noncardiac causes. Myocardial blocks four standard sites in left ventricle were analyzed for water, sodium, potassium, chloride, magnesium, phosphorus twenty-nine cases potassium eighteen additional cases; pectoralis major all six substances twenty-five cases. control group comprised sixteen normal hearts at autopsy no evidence a metabolic disorder. analyses yielded averages 78.8 Gm. 4.96 meq. 8.32 4.04 0.445 3.88 per 100 wet tissue. Estimates partition between extracellular intracellular compartments concentrations base within cells made according to method Newburgh. Skeletal same comparable myocardium total content, but showed relatively smaller larger volume. concentration essentially as that myocardium, sodium level slightly higher magnesium levels lower. Uncomplicated ventricular hypertrophy found fourteen who during hospitalization died average each almost identical group. Congestive failure, complicating hypertrophy, present eight patients. Analyses significant reduction below values, change phosphorus. estimated both similar controls. reduced muscle, largely loss. significance these observations is discussed. Recent responsible death seven Separate infarcted areas distant appeared uninfarcted gross examination. Infarcted marked proportionate increase reflecting severe interstitial edema, an even more phosphorus, primarily losses dead cells. not grossly gave results five electrolytes intermediate values obtained segments those abnormalities chemical well beyond boundaries infarct attributed ischemia. Analysis did deviate significantly normal.