Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia.

摘要: Recent studies have indicated that the interleukin-12/interferon-γ (IFN-γ) axis is important in mycobacterial infection susceptibility. Using an intronic (CA)n polymorphic microsatellite marker within IFN-γ receptor-1 (IFNGR1) gene, we compared allelic frequencies of this hospitalized tuberculosis patients (n = 120) with controls (n = 87) from Rijeka, Croatia. We identified 13 alleles patients, whereas only 10 were found controls. A significant difference between one and control group was observed (P = 0.02, 95% confidence interval 0.14–0.94), suggesting a possible protective association. In contrast, several other markers showed trend towards association disease. also increased frequency homozygosity (11.7%) as (4.6%). conclude there no evidence for disease IFNGR1 gene Mendelian-type (single-allele) inheritance. However, our results suggest unidentified variations might elevate or decrease risk ethnic population, part multigenic predisposition to tuberculosis.