A physiological perspective on the neuroscience of eating.

摘要: Abstract I present the thesis that ‘being physiological,’ i.e., analyzing eating under conditions do not perturb, or minimally organism's endogenous processes, should be a central goal of neuroscience eating. describe my understanding physiological’ based on [i] neural-network heuristic CNS function traces back to Cajal and Sherrington, [ii] research one simpler problems in eating, identification endocrine signals control In this context consider natural meals, physiological doses ranges, antagonist studies. Several examples involve CCK. Next view cutting edge molecular as it has evolved from discovery leptin signaling through application optogenetic pharmacogenetic methods. Finally some novel approaches may advance foreseeable future. conclude soon able discern ‘physiological’ operation networks mediating capitalize methods developed other areas neuroscience, e.g., improved record manipulate behaving animals, canonical regional circuits, use population electrophysiology, etc., [iii] subjective aspects are crucial science, but remain beyond mechanistic understanding.