Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation.

摘要: Abstract An exceptionally high mortality rate is observed in sepsis and septic shock. Systemic administration of lipopolysaccharide (LPS) has been used as an experimental model for resulting exacerbated immune response, brain neurochemistry adjustments, hypotension, hypothermia followed by fever. Central serotonergic pathways not only modulate systemic inflammation (SI) but also are affected SI, including the anteroventral region hypothalamus (AVPO), which hierarchically most important body temperature (Tb) control. In this study, we sought to determine if central serotonin (5-HT) plays a role SI induced intravenous LPS (1.5 mg/kg) male Wistar rats (280–350 g) assessing 5-HT levels AVPO, mean arterial pressure, heart rate, Tb up 300 min after administration, well plasma spleen cytokine levels, nitric oxide (NO) prostaglandin (PG) E2 AVPO at 75 min administration. We reduced tachycardia, fever, observing increased NO, cytokines PGE2 SI. Intracerebroventricular (icv) 30 min before prevented hypotension hypothermia, were accompanied TNF-α, IL-1β, IL-6, IL-10 TNF-α levels. suggest that favor pro-inflammatory status both centrally peripherally converge hypothermia. Moreover, our results consistent with notion exogenous given icv prevents probably activating splenic anti-inflammatory pathway.