Nitrite attenuated hypochlorous acid-mediated heme degradation in hemoglobin
作者： Naihao Lu , Jiayu Li , Xiaoming Ren , Rong Tian , Yi-Yuan Peng
DOI: 10.1016/J.CBI.2015.05.021
关键词: Biochemistry 、 Nitrite 、 Hemeprotein 、 Peroxidase 、 Radical 、 Hypochlorous acid 、 Hemoglobin 、 Chemistry 、 Myeloperoxidase 、 Heme
摘要: Hypochlorous acid (HOCl) is elevated in many inflammatory diseases and causes the accumulation of free iron. Through Fenton reaction, iron has ability to generate radicals subsequently toxic. Recent studies have demonstrated that HOCl participates heme destruction hemoglobin (Hb) release. In this study, it was showed nitrite (NO2−) could prevent HOCl-mediated Hb Also, NO2− prevented loss peroxidase activity. After NO2−/HOCl treatment, Tyr 42 α-chain found be nitrated Hb, attenuating electron transferring abilities phenolic compounds. The protective effects on HOCl-induced were attributed its reduction ferryl and/or direct scavenging HOCl. Therefore, show some by preventing hemoproteins
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