Brain-derived neurotrophic factor levels in Alzheimer's disease.
作者： Sid E. O'Bryant , Valerie Hobson , James R. Hall , Stephen C. Waring , Wenyan Chan
关键词: Neurotrophic factors 、 Alzheimer's disease 、 Oncology 、 Mental Status Schedule 、 Brain-derived neurotrophic factor 、 Cohort study 、 Neuroscience 、 Clinical Dementia Rating 、 Cohort 、 Disease 、 Internal medicine 、 Psychology
摘要: The current search for biomarkers that are diagnostic and/or prognostic of Alzheimer's disease (AD) is vital importance given the rapidly aging population. It was recently reported brain-derived neurotrophic factor (BDNF) fluctuated according to AD severity, suggesting BDNF might have utility diagnostics and monitoring therapeutic efficacy. study sought examine whether levels varied as previously reported. There were 196 participants (Probable AD, n = 98; Controls, 98) in Texas Research Consortium (TARC) Longitudinal Cohort available analysis. assayed via multiplex immunoassay. Regression analyses utilized relation between levels, Mini-Mental Status Examination, Clinical Dementia Rating scores adjusting age gender. In adjusted models, did not distinguish patients normal controls significantly predict severity or global cognitive functioning. conclusion, these findings do support notion serves a marker severity. likely most accurate approach identifying will be through an algorithmic combines multiple markers reflective various pathways.
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